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Yonsei Med J. 2018 Mar;59(2):176-186. doi: 10.3349/ymj.2018.59.2.176.

Systems Biology-Based Platforms to Accelerate Research of Emerging Infectious Diseases.

Author information

1
Department of Biomedical Sciences, College of Medicine, Korea University Guro Hospital, Seoul, Korea.
2
College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Korea.
3
Department of Biomedical Sciences, College of Medicine, Korea University Guro Hospital, Seoul, Korea. oshin@korea.ac.kr.

Abstract

Emerging infectious diseases (EIDs) pose a major threat to public health and security. Given the dynamic nature and significant impact of EIDs, the most effective way to prevent and protect against them is to develop vaccines in advance. Systems biology approaches provide an integrative way to understand the complex immune response to pathogens. They can lead to a greater understanding of EID pathogenesis and facilitate the evaluation of newly developed vaccine-induced immunity in a timely manner. In recent years, advances in high throughput technologies have enabled researchers to successfully apply systems biology methods to analyze immune responses to a variety of pathogens and vaccines. Despite recent advances, computational and biological challenges impede wider application of systems biology approaches. This review highlights recent advances in the fields of systems immunology and vaccinology, and presents ways that systems biology-based platforms can be applied to accelerate a deeper understanding of the molecular mechanisms of immunity against EIDs.

KEYWORDS:

Emerging infectious diseases; immunity; systems biology; systems vaccinology; vaccines

PMID:
29436184
PMCID:
PMC5823818
DOI:
10.3349/ymj.2018.59.2.176
[Indexed for MEDLINE]
Free PMC Article

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