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Oncotarget. 2017 Dec 21;9(4):4915-4923. doi: 10.18632/oncotarget.23518. eCollection 2018 Jan 12.

Arsenic exposure assists ccm3 genetic polymorphism in elevating blood pressure.

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Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, Sun Yat-sen University School of Public Health, Guangzhou, Guangdong 510080, China.
Gannan Medical University, Ganzhou, Jiangxi 341000, China.
Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong 518055, China.
Zhongshan Center for Disease Control and Prevention, Zhongshan, Guangdong 528400, China.
Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen, Guangdong 518020, China.
Contributed equally


Epidemiologic study has suggested that arsenic exposure is positively related to increased blood pressure. However, the underlying mechanism concerning interaction between genetic polymorphisms and arsenic exposure remains unclear. In present study, within 395 Chinese, the effects of interaction between arsenic exposure and CCM3 gene polymorphisms on elevation of blood pressure were probed by multiple Logistic regression models after adjusting for confounding factors. Firstly, we found that serum arsenic was positively associated with blood pressure, cholesterol, glucose and C-reactive protein. Then, adjusted for confounding factors of age, gender, smoking, alcohol consumption, BMI and degree of education, arsenic exposure incurred the hazard of increased systolic pressure and diastolic pressure, with odds ratios (ORs) being 1.725 and 1.425, respectively. Distinctly, we found that interactions between rs3804610* rs9818496, rs6784267*rs9818496, and rs3804610* rs6784267 variant genotype can increase significantly risks of SBP. Additionally, interactions between rs9818496, rs3804610 and rs6784267 genotypic variantions and arsenic exposure boosted the hazard of increased systolic pressure, with ORs being 1.496, 1.496 and 1.312. In conclusion, our fingdings suggest that As exposure of population can assist CCM3 polymorphism in elevating SBP.


CCM3; arsemic exposure; blood presssure; genetic polymorphism

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

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