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Indian J Microbiol. 2018 Mar;58(1):105-108. doi: 10.1007/s12088-017-0693-x. Epub 2017 Nov 21.

In Vitro Antibacterial Activity of Phlorotannins from Edible Brown Algae, Eisenia bicyclis Against Streptomycin-Resistant Listeria monocytogenes.

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1Department of Food Science and Technology, Pukyong National University, Busan, 48547 Korea.
2Marine-Integrated Bionics Research Center, Pukyong National University, Busan, 48513 Korea.
3Department of Food Science and Technology, Dongeui University, Busan, 47340 Korea.


Listeria monocytogenes (LM) is an important food borne pathogen responsible for listeriosis. Further, LM is an etiological agent associated with life threatening conditions like meningitis and encephalitis. Biofilm forming and drug resistant LM may potentially become difficult to treat infections and hence effective controlling measures are required to prevent LM infections. In view of this, the present study evaluated an anti-listerial potential of edible brown seaweed, Eisenia bicyclis, by disc diffusion and micro-dilution methods. The results of the present study suggested that the anti-listerial activity of various phlorotannins isolated form E. bicyclis were in the range of 16-256 µg/ml. Among the phlorotannins isolated, fucofuroeckol-A (FAA) exhibited the highest anti-listerial potential (MIC range 16-32 µg/ml) against LM strains tested. Further, in checker board synergy assays, FFA-streptomycin combination exhibited significant synergy (fractional inhibitory concentration index, ∑FIC < 0.5) against aminoglycoside resistant clinical strains of LM. The results of the present study suggested the potential use of edible seaweed E. bicyclis as a source of natural phlorotannins to control food borne pathogenic infections.


Anti-listerial agents; Antibiotic resistance; Eisenia bicyclis; Phlorotannins

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