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Food Res Int. 2018 Mar;105:589-598. doi: 10.1016/j.foodres.2017.11.063. Epub 2017 Nov 26.

Ethyl acetate fraction from Hibiscus sabdariffa L. attenuates diabetes-associated cognitive impairment in mice.

Author information

1
Division of Applied Life Science(BK21 plus), Institute of Agricultural and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea. Electronic address: twseung@naver.com.
2
Division of Applied Life Science(BK21 plus), Institute of Agricultural and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea. Electronic address: tjsrud2510@naver.com.
3
Division of Applied Life Science(BK21 plus), Institute of Agricultural and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea. Electronic address: kangjy2132@naver.com.
4
Division of Applied Life Science(BK21 plus), Institute of Agricultural and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea. Electronic address: myrock201@naver.com.
5
Division of Applied Life Science(BK21 plus), Institute of Agricultural and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea. Electronic address: gughon@naver.com.
6
Division of Applied Life Science(BK21 plus), Institute of Agricultural and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea. Electronic address: kbs4101@naver.com.
7
Division of Applied Life Science(BK21 plus), Institute of Agricultural and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea. Electronic address: getupcat@naver.com.
8
Division of Applied Life Science(BK21 plus), Institute of Agricultural and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea. Electronic address: kid940225@naver.com.
9
Department of Food Science and Biotechnology, Kyung Hee University, Yongin 17104, Republic of Korea. Electronic address: dokim05@khu.ac.kr.
10
Division of Special Purpose Trees, National Institute of Forest Science, Suwon 16631, Republic of Korea. Electronic address: rich26@korea.kr.
11
Division of Applied Life Science(BK21 plus), Institute of Agricultural and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea. Electronic address: hjher@gnu.ac.kr.

Abstract

The ameliorating effects of the ethyl acetate fraction from Hibiscus sabdariffa L. (EFHS)2 against diabetes mellitus (DM)3 and DM-induced cognitive impairment were investigated on streptozotocin (STZ)4-induced DM mice. The EFHS groups showed improved hyperglycemia and glucose tolerance compared to the STZ group. Furthermore, their liver and kidney function and lipid metabolic imbalance in the blood serum were effectively recovered. The EFHS groups significantly ameliorated STZ-induced cognitive impairment in Y-maze, passive avoidance, and Morris water maze (MWM)5 tests. The EFHS groups showed significant improvement in the antioxidant and cholinergic systems of the brain tissue. In addition, EFHS had an excellent ameliorating effect on protein expression levels from the tau hyperphosphorylation pathways, such as phospho-c-Jun N-terminal kinases (p-JNK),6 phospho-tau (p-tau),7 and cleaved poly (ADP-ribose) polymerase (c-PARP).8 The main compounds of EFHS were identified as various phenolic compounds, including hibiscus acid, caffeoylquinic acid (CQA)9 isomers, and quercetin derivates. Therefore, EFHS containing various physiologically active materials can potentially be used for improving DM-induced cognitive impairment via its antioxidant activity, improvement of the cholinergic system, and hyperphosphorylation tau signaling.

KEYWORDS:

Cognitive function; Diabetes mellitus; Hibiscus sabdariffa L.; Streptozotocin

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