Format

Send to

Choose Destination
Cytokine. 2018 May;105:17-22. doi: 10.1016/j.cyto.2018.02.006. Epub 2018 Feb 9.

Effect of strenuous exercise on mediators of inflammation in patients with coronary artery disease.

Author information

1
Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevaal, Norway; Faculty of Medicine, University of Oslo, Norway; Section of Cardiovascular and Renal Research, Oslo University Hospital Ulleval, Norway. Electronic address: joacwi@ous-hf.no.
2
Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevaal, Norway; Department of Cardiology, Oslo University Hospital Ullevaal, Norway; Faculty of Medicine, University of Oslo, Norway. Electronic address: uxinlj@ous-hf.no.
3
Department of Cardiology, Oslo University Hospital Ullevaal, Norway. Electronic address: eivind.berge@medisin.uio.no.
4
Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevaal, Norway. Electronic address: idaunh@ous-hf.no.
5
Modum Bad, Vikersund, Norway. Electronic address: hildeulsaker@gmail.com.
6
Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevaal, Norway; Faculty of Medicine, University of Oslo, Norway. Electronic address: uxhaar@ous-hf.no.
7
Department of Cardiology, Oslo University Hospital Ullevaal, Norway; Section of Cardiovascular and Renal Research, Oslo University Hospital Ulleval, Norway. Electronic address: arnljot.flaa@gmail.com.

Abstract

BACKGROUND:

Coronary artery disease (CAD) is considered a low-grade inflammatory disease. We aimed to identify effects of short-term strenuous exercise on mediators of systemic inflammation, endothelial and platelet activation in patients with angiographically verified CAD. We hypothesized that a more pronounced inflammatory response would be present in patients with CAD than in those without CAD.

METHODS:

In subjects with symptoms indicative of stable CAD, an exercise stress test on a bicycle ergometer was performed. Venous blood samples, taken at rest and within 5 min after end of exercise, were analyzed for the following markers by ELISAs: TNF-α, IL-6, MCP-1, ICAM-1, VCAM-1, E-selectin, P-selectin, CD40L and RANTES. All participants underwent conventional coronary angiography. CAD was defined as having any degree of atherosclerosis.

RESULTS:

A total of 110 patients were included, of whom 74 were found to have CAD. Mean exercise duration was 10:06 ± 3:56 min with no significant difference between the two groups. All measured markers changed significantly during exercise (p ≤ 0.012). A significantly less pronounced increase in CD40L in the CAD group than in the no CAD group was observed (p = 0.050), however, after adjustment for hematocrit this difference was no longer significant.

CONCLUSION:

An instant inflammatory response was observed during short-term strenuous exercise in patients with symptoms of CAD. However, the exercise mediated response was not more pronounced in patients with CAD.

KEYWORDS:

Angiography; Atherosclerosis; Exercise testing; Inflammatory biomarkers

PMID:
29433015
DOI:
10.1016/j.cyto.2018.02.006

Supplemental Content

Full text links

Icon for Elsevier Science Icon for Norwegian BIBSYS system
Loading ...
Support Center