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Evid Based Complement Alternat Med. 2017;2017:3647801. doi: 10.1155/2017/3647801. Epub 2017 Dec 21.

Anti-Inflammatory Activity of Babassu Oil and Development of a Microemulsion System for Topical Delivery.

Author information

1
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual da Paraíba, Rua Juvêncio Arruda S/N, Bairro Universitário, 58429-600 Campina Grande, PB, Brazil.
2
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
3
Departamento de Bioquímica, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
4
Departamento de Química Fundamental, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
5
Programas de Pós-Graduação em Engenharia e Ciência dos Materiais e Ciências da Saúde, Universidade de Caxias do Sul, Rua Francisco Getúlio Vargas, No. 1130, Petrópolis, 95070-560 Caxias do Sul, RS, Brazil.
6
Departamento de Antibióticos, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil.
7
Faculdade Boa Viagem, DeVry, Av. Jean Emile Favre, No. 422, Imbiribeira, 61200-060 Recife, PE, Brazil.
8
Laboratório de Microscopia e Microanálise, Centro de Tecnologias Estratégicas do Nordeste, Av. Prof. Luís Freire, No. 1, Cidade Universitária, 50740-540 Recife, PE, Brazil.
9
Núcleo de Plataformas Tecnológicas, Instituto Aggeu Magalhães, FIOCRUZ, Av. Prof. Moraes Rego S/N, Cidade Universitária, 50740-465 Recife, PE, Brazil.

Abstract

Babassu oil extraction is the main income source in nut breakers communities in northeast of Brazil. Among these communities, babassu oil is used for cooking but also medically to treat skin wounds and inflammation, and vulvovaginitis. This study aimed to evaluate the anti-inflammatory activity of babassu oil and develop a microemulsion system with babassu oil for topical delivery. Topical anti-inflammatory activity was evaluated in mice ear edema using PMA, arachidonic acid, ethyl phenylpropiolate, phenol, and capsaicin as phlogistic agents. A microemulsion system was successfully developed using a Span® 80/Kolliphor® EL ratio of 6 : 4 as the surfactant system (S), propylene glycol and water (3 : 1) as the aqueous phase (A), and babassu oil as the oil phase (O), and analyzed through conductivity, SAXS, DSC, TEM, and rheological assays. Babassu oil and lauric acid showed anti-inflammatory activity in mice ear edema, through inhibition of eicosanoid pathway and bioactive amines. The developed formulation (39% A, 12.2% O, and 48.8% S) was classified as a bicontinuous to o/w transition microemulsion that showed a Newtonian profile. The topical anti-inflammatory activity of microemulsified babassu oil was markedly increased. A new delivery system of babassu microemulsion droplet clusters was designed to enhance the therapeutic efficacy of vegetable oil.

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