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BMB Rep. 2018 Apr;51(4):194-199.

Human amnion-derived mesenchymal stem cells induced osteogenesis and angiogenesis in human adipose-derived stem cells via ERK1/2 MAPK signaling pathway.

Author information

1
Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029; Departments of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China.
2
Analysis Center, Nanjing Medical University, Nanjing 211166, China.
3
Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China.
4
Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029; Departments of Periodontology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China.

Abstract

Mesenchymal stem cells (MSCs) have shown great potential in treating bone deficiency. Human adipose-derived stem cells (HASCs) are multipotent progenitor cells with multi-lineage differentiation potential. Human amnion-derived mesenchymal stem cells (HAMSCs) are capable of promoting osteogenic differentiation of MSCs. In this study, we investigated the effect of HAMSCs on HASCs by a transwell co-culture system. HAMSCs promoted proliferation, osteogenic differentiation, angiogenic potential and adiponectin (APN) secretion of HASCs. Moreover, the positive effect of HAMSCs was significantly inhibited by U0126, a highly selective inhibitor of extracellular signaling-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) signaling pathway. These observations suggested that HAMSCs induced bone regeneration in HASCs via ERK1/2 MAPK signaling pathway. [BMB Reports 2018; 51(4): 194-199].

PMID:
29429450
PMCID:
PMC5933215
DOI:
10.5483/bmbrep.2018.51.4.005
[Indexed for MEDLINE]
Free PMC Article

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