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Clin Nutr. 2019 Feb;38(1):258-263. doi: 10.1016/j.clnu.2018.01.023. Epub 2018 Feb 15.

A pilot study of a novel therapeutic approach to obesity: CNS modification by N.I.R. H.E.G. neurofeedback.

Author information

1
The Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, 52621, Israel; The Cancer Center, Sheba Medical Center, Israel. Electronic address: ruthpercik@gmail.com.
2
The Weight Loss Treatment Center, Sheba Medical Center, Israel.
3
Department of Diagnostic Imaging, Sheba Medical Center, Israel; Joseph Sagol Neuroscience Center, Sheba Medical Center, Israel.
4
The Complementary & Integrative Medicine Service, Sheba Medical Center, Israel.
5
Integristats: Clinical Data Services, Israel.
6
Department of Internal Medicine A, Sheba Medical Center, Israel.

Abstract

BACKGROUND & AIMS:

Despite the thorough mapping of brain pathways involved in eating behavior, no treatment aimed at modulating eating dysregulation from its neurocognitive root has been established yet. We aimed to evaluate the effect of N.I.R. H.E.G. (Near Infra-Red Hemoencephalography) neurofeedback training on appetite control, weight and food-related brain activity.

METHODS:

Six healthy male participants with overweight or mild obesity went through 10 N.I.R. H.E.G. neurofeedback sessions designed to practice voluntary activation of the prefrontal cortex. Weight, eating behavior, appetite control and brain activity related to food and self-inhibition based on fMRI were evaluated before and after neurofeedback training.

RESULTS:

Our study group demonstrated a positive trend of increased self-control and inhibition related to food behavior, reduced weight and increased activation during an fMRI response-inhibition task (Go-No-Go - GNG) in the predefined region of interest (ROI): superior orbitofrontal cortex (sOFC).

CONCLUSIONS:

N.I.R. H.E.G. holds a promising potential as a feasible neurofeedback platform for modulation of cortical brain circuits involved in self-control and eating behavior and should be further evaluated and developed as a brain modifying device for the treatment and prevention of obesity.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT02480179.

KEYWORDS:

Executive functions; Mindfulness; Neurofeedback; Neuroimaging; Obesity treatment

PMID:
29428788
DOI:
10.1016/j.clnu.2018.01.023
[Indexed for MEDLINE]

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