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Obesity (Silver Spring). 2018 Apr;26(4):703-712. doi: 10.1002/oby.22128. Epub 2018 Feb 10.

Longitudinal Increases in Adiposity Contribute to Worsening Adipokine Profile over Time in Mexican Americans.

Author information

1
Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
2
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
3
Diabetes and Obesity Research Institute, University of Southern California, Los Angeles, California, USA.
4
Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
5
Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Abstract

OBJECTIVE:

Limited studies have assessed the relationship between longitudinal changes in adiposity and changes in multiple adipokines over time. This study examined changes in BMI, total body fat, and trunk fat associated with changes in 16 circulating adipokines in Mexican Americans at risk for type 2 diabetes.

METHODS:

Participants included 1,213 individuals with cross-sectional data and a subset of 368 individuals with follow-up measures (mean 4.6 ± 1.5 years from baseline). Joint multivariate associations between 3 adiposity measures and 16 adipokines were assessed by canonical correlation analysis.

RESULTS:

Longitudinal increases in adiposity were most strongly associated with increasing leptin, C-reactive protein (CRP), and interleukin 1 receptor antagonist (IL-1Ra) and decreasing adiponectin and secreted frizzled protein 5 (SFRP5) over time. Participants with BMI ≥ 30 kg/m2 at baseline had greater increases in leptin, CRP, IL-1Ra, and interleukin 6 (IL-6) and greater decreases in adiponectin and SFRP5, associated with increasing adiposity over follow-up, than those with BMI < 30 kg/m2 . Associations between adiposity and adipokines were most accounted for by leptin; adjustment for leptin greatly reduced the magnitude of all associations between adiposity and remaining adipokines.

CONCLUSIONS:

Increasing adiposity contributes to a worsening imbalance of pro- and anti-inflammatory adipokines over time, in which leptin may have an important role as a key mediator of metabolic disease risk in Mexican Americans.

PMID:
29427376
PMCID:
PMC6021026
DOI:
10.1002/oby.22128
[Indexed for MEDLINE]
Free PMC Article

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