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Neurol Sci. 2018 Apr;39(4):691-698. doi: 10.1007/s10072-018-3276-7. Epub 2018 Feb 9.

Association of MTHFR gene polymorphisms with migraine in North Indian population.

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Department of Biosciences, UGC-PDF, Gene Expression Lab, Jamia Millia Islamia, New Delhi, India.
Department of Biosciences, UGC-BSR-FF, Jamia Millia Islamia, New Delhi, India.
Department of Physiology, ESIC Medical College & Hospital, Faridabad, India.
NC Medical College & Hospital, Panipat, India.


Polymorphisms in MTHFR gene are mostly associated with increased levels of homocysteine in the absence of dietary folate and are a risk factor for complex neurovascular diseases like migraine. The aim of present case-control study was to determine the association between MTHFR gene polymorphisms (C667T; rs 1801133, A1298C; rs 1801131) with migraine susceptibility. In total, 100 patients with migraine (23with MA and 77 with MO) and age-sex matched 100 healthy controls were included in this study from OPD of ESIC Medical College & Hospital, Faridabad. Genotyping was done by PCR-RFLP method. Genotypic and allelic frequencies were compared by SPSS 24 version. Genotypic results indicated a non-significant increase in frequencies of CT and TT in C667T SNP in migraine patients with control (52 and 10% vs. 42 and 7%: p > 0.05), but CC genotype in A1298C was found to be a risk factor in migraine patients than controls (30 vs. 17% respectively: p < 0.05). On comparing migraine subclasses, migraine with aura (MA) and without aura (MO) with control groups, the present study suggests that in MTHFR polymorphisms, the prevalence of 677CT genotype and T allele in C667T SNP influences susceptibility to MA (p < 0.05) but not to MO. Meanwhile, CC genotype in A1298C SNP could be a risk factor for migraine patients without aura (p < 0.05).


MTHFR gene; Migraine; Single nucleotide polymorphisms; rs 1801131; rs 1801133

[Indexed for MEDLINE]

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