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Int J Biol Macromol. 2018 Jun;112:1055-1061. doi: 10.1016/j.ijbiomac.2018.01.183. Epub 2018 Feb 7.

Digestibility of sulfated polysaccharide from the brown seaweed Ascophyllum nodosum and its effect on the human gut microbiota in vitro.

Author information

1
College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, PR China; School of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng 224051, China; Jiangsu Key Laboratory of Biochemistry and Biotechnology of Marine Wetland, Yancheng Institute of Technology, Yancheng 224051, PR China.
2
School of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng 224051, China; Jiangsu Key Laboratory of Biochemistry and Biotechnology of Marine Wetland, Yancheng Institute of Technology, Yancheng 224051, PR China. Electronic address: ycitxuwei@ycit.edu.cn.
3
College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China.
4
School of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng 224051, China.
5
Jiangsu Key Laboratory of Biochemistry and Biotechnology of Marine Wetland, Yancheng Institute of Technology, Yancheng 224051, PR China.
6
College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, PR China. Electronic address: zhuhj@njtech.edu.cn.

Abstract

Sulfated polysaccharides from marine algae exhibit various bioactivities with potential benefits for human health and well-being. In this study, the in vitro digestibility and fermentability of polysaccharides from the brown seaweed Ascophyllum nodosum (AnPs) were examined, and the effects of AnPs on gut microbiota were determined using high-throughput sequencing technology. Salivary amylase, artificial gastric juice, and intestinal juice had no effect on AnPs, but the molecular weight of AnPs and reducing sugar decreased significantly after fermentation by gut microbiota. AnPs significantly modulated the composition of the gut microbiota; in particular, they increased the relative abundance of Bacteroidetes and Firmicutes, suggesting the potential for AnPs to decrease the risk of obesity. Furthermore, the total SCFA content after fermentation increased significantly. These results suggest that AnPs have potential uses as functional food components to improve human gut health.

KEYWORDS:

Ascophyllum nodosum; Gut microbiota; In vitro digestibility; Polysaccharide; Short chain fatty acid

PMID:
29425873
DOI:
10.1016/j.ijbiomac.2018.01.183
[Indexed for MEDLINE]

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