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Eur J Pharmacol. 1986 May 27;124(3):361-3.

Suppression of lordosis behavior by the putative 5-HT receptor agonist 8-OH-DPAT in the rat.

Abstract

The administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), inhibited the lordosis induced by estradiol benzoate or estradiol benzoate plus progesterone in ovariectomized rats. There was no facilitation of lordosis by 8-OH-DPAT in animals pretreated with a threshold dose of estradiol benzoate. The results are consistent with the view that 8-OH-DPAT is an agonist at 5-HT receptors and provide further support for an inhibition role of central 5-HT in the mediation of lordosis behavior.

PMID:
2942412
DOI:
10.1016/0014-2999(86)90241-4
[Indexed for MEDLINE]

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