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Anal Bioanal Chem. 2018 Mar;410(8):2053-2057. doi: 10.1007/s00216-018-0899-8. Epub 2018 Feb 9.

The 2017 Nobel Prize in Chemistry: cryo-EM comes of age.

Author information

1
Department of Biochemistry, University of Utah, Salt Lake City, UT, 84112, USA. peter.shen@biochem.utah.edu.

Abstract

The 2017 Nobel Prize in Chemistry was awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson for "developing cryo-electron microscopy (cryo-EM) for the high-resolution structure determination of biomolecules in solution." This feature article summarizes some of the major achievements leading to the development of cryo-EM and recent technological breakthroughs that have transformed the method into a mainstream tool for structure determination.

KEYWORDS:

Cryo-EM; Nobel Prize; Structural biology; TEM

PMID:
29423601
DOI:
10.1007/s00216-018-0899-8
[Indexed for MEDLINE]

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