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Mol Autism. 2018 Jan 30;9:9. doi: 10.1186/s13229-018-0195-7. eCollection 2018.

Altered reward system reactivity for personalized circumscribed interests in autism.

Author information

1
1Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
2
2Department of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, VA USA.
3
3Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
4
4Center for Autism Research, The Children's Hospital of Philadelphia, 3535 Market Street, Ste 860, Philadelphia, PA 19104 USA.
5
5Pediatrics Department, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
6
6Psychiatry Department, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.

Abstract

Background:

Neurobiological research in autism spectrum disorders (ASD) has paid little attention on brain mechanisms that cause and maintain restricted and repetitive behaviors and interests (RRBIs). Evidence indicates an imbalance in the brain's reward system responsiveness to social and non-social stimuli may contribute to both social deficits and RRBIs. Thus, this study's central aim was to compare brain responsiveness to individual RRBI (i.e., circumscribed interests), with social rewards (i.e., social approval), in youth with ASD relative to typically developing controls (TDCs).

Methods:

We conducted a 3T functional magnetic resonance imaging (fMRI) study to investigate the blood-oxygenation-level-dependent effect of personalized circumscribed interest rewards versus social rewards in 39 youth with ASD relative to 22 TDC. To probe the reward system, we employed short video clips as reinforcement in an instrumental incentive delay task. This optimization increased the task's ecological validity compared to still pictures that are often used in this line of research.

Results:

Compared to TDCs, youth with ASD had stronger reward system responses for CIs mostly within the non-social realm (e.g., video games) than social rewards (e.g., approval). Additionally, this imbalance within the caudate nucleus' responsiveness was related to greater social impairment.

Conclusions:

The current data support the idea of reward system dysfunction that may contribute to enhanced motivation for RRBIs in ASD, accompanied by diminished motivation for social engagement. If a dysregulated reward system indeed supports the emergence and maintenance of social and non-social symptoms of ASD, then strategically targeting the reward system in future treatment endeavors may allow for more efficacious treatment practices that help improve outcomes for individuals with ASD and their families.

KEYWORDS:

Autism spectrum disorders; Caudate nucleus; Circumscribed interests; Functional magnetic resonance imaging; Motivation; Restricted and repetitive behaviors and interests; Reward; Reward system; Striatum

PMID:
29423135
PMCID:
PMC5791309
DOI:
10.1186/s13229-018-0195-7
[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

All study procedures were approved by the institutional review board of the Children’s Hospital of Philadelphia. Written informed consent was obtained from all participants and their parents or legal guardians.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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