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Gastroenterol Hepatol. 2018 Mar;41(3):191-204. doi: 10.1016/j.gastrohep.2017.12.002. Epub 2018 Feb 13.

New coeliac disease treatments and their complications.

[Article in English, Spanish]

Author information

1
Servicio de Aparato Digestivo, Complejo Asistencial Universitario de León, León, España.
2
Celimmune, Bethesda, Maryland, Estados Unidos.
3
Servicio de Aparato Digestivo, Complejo Asistencial Universitario de León, León, España; Instituto de Biomedicina (IBIOMED), Universidad de León, León, España.
4
Servicio de Aparato Digestivo, Complejo Asistencial Universitario de León, León, España; Instituto de Biomedicina (IBIOMED), Universidad de León, León, España. Electronic address: svivasa@gmail.com.

Abstract

The only accepted treatment for coeliac disease is strict adherence to a gluten-free diet. This type of diet may give rise to reduced patient quality of life with economic and social repercussions. For this reason, dietary transgressions are common and may elicit intestinal damage. Several treatments aimed at different pathogenic targets of coeliac disease have been developed in recent years: modification of gluten to produce non-immunogenic gluten, endoluminal therapies to degrade gluten in the intestinal lumen, increased gluten tolerance, modulation of intestinal permeability and regulation of the adaptive immune response. This review evaluates these coeliac disease treatment lines that are being researched and the treatments that aim to control disease complications like refractory coeliac disease.

KEYWORDS:

Coeliac disease; Dieta sin gluten; Enfermedad celiaca; Enteropatía sensible al gluten; Gluten-free diet; Gluten-sensitive enteropathy

PMID:
29422237
DOI:
10.1016/j.gastrohep.2017.12.002
[Indexed for MEDLINE]

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