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Oncol Res. 2018 Feb 8. doi: 10.3727/096504018X15178798885361. [Epub ahead of print]

MicroRNA-139-3p suppresses tumor growth and metastasis in hepatocellular carcinoma by repressing ANXA2R.

Author information

1
Department of Integrated Traditional and Western Medicine, The Third Affiliated Hospital of SunYat-sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou 510630, China.
2
Department of Oncology,Guangdong Provincial Hospital of Traditional Chinese Medicine,No. 36 Huadi, YongAn Street, Liwan District, Guangzhou 510120, China.
3
Department of Hepatobiliary Surgery, The Third Affiliated Hospital of SunYat-sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou 510630, China.
4
Department of acupuncture,Guangdong Provincial Hospital of Traditional Chinese Medicine, No. 36 Huadi, YongAn Street, Liwan District, Guangzhou 510120, China.
5
Department of Infertility and Sterility,Guangdong Provincial Family Planning Research Institute, No. 17 Meidong Road, Yuexiu District, Guangzhou 510600, China.

Abstract

The direct roles of miR-139-3p on hepatocellular carcinoma (HCC) cell growth and metastasis remain poorly understood. We attempt to demonstrate the regulatory role of miR139-3p in hepatocellular carcinoma (HCC) progression and its mechanisms behind. Here, we show that miR-139-3p expression was significantly reduced in the HCC tissues compared to para-tumor tissues. Exogenous overexpression of miR-139-3p inhibited the migration and invasion of HCC cells, whereas down-regulation of miR-139-3p was able to induced HCC HepG2 and SNU-449 cell lines migration and invasion. In addition, miR-139-3p inhibited HCC growth and lung metastasis in vivo mouse model, which is mainly regulated by Annexin A2 Receptor (ANXA2R). Finally, we identified the expression of miR-139-3p was inversely correlated with ANXA2R expression in human HCC tissue. All these results demonstrated that miR-139-3p inhibited the metastasis process in HCC by down-regulating ANXA2R expression.

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