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Phytochemistry. 2018 Apr;148:87-96. doi: 10.1016/j.phytochem.2018.01.019. Epub 2018 Feb 6.

Anti-inflammatory steroidal glycosides from the berries of Solanum nigrum L. (European black nightshade).

Author information

1
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China.
2
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China. Electronic address: hexj@gdpu.edu.cn.

Abstract

Seven previously undescribed steroidal glycosides, along with three known congeners were isolated from the unripe berries of Solanum nigrum L. (Solanaceae). Their structures were elucidated on basis of 1D and 2D NMR, HR-ESI-MS spectroscopic data and GC analysis after acid hydrolysis. The potential inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide in RAW 264.7 cell line and the anti-proliferative activities against five cancer cell lines (HL-60, U-937, Jurkat, K562 and HepG2) were evaluated. Seven compounds exhibited inhibition activities on NO production with IC50 values ranging from 11.33 to 49.35 μM. Structure-activity relationships of the isolated compounds were also discussed.

KEYWORDS:

Anti-inflammatory activity; Solanaceae; Solanum nigrum L.; Steroidal glycosides

PMID:
29421515
DOI:
10.1016/j.phytochem.2018.01.019
[Indexed for MEDLINE]

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