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Environ Int. 2018 Apr;113:66-73. doi: 10.1016/j.envint.2018.01.013. Epub 2018 Feb 6.

Prenatal exposure to glycol ethers and sex steroid hormones at birth.

Author information

1
Inserm UMR 1085 Irset, Exposure Assessment and Epidemiological Research on Environment, Reproduction and Development, F-35000 Rennes, France; Université de Rennes I, F-35043 Rennes, France.. Electronic address: charline.warembourg@gmail.com.
2
Inserm UMR 1085 Irset, Exposure Assessment and Epidemiological Research on Environment, Reproduction and Development, F-35000 Rennes, France; Université de Rennes I, F-35043 Rennes, France.
3
AP-HP, Pôle biologie-Pathologie Henri Mondor, Créteil 94000, France.; INSERM U955 eq07, Recherche Translationnelle en oncogenèse génitale, Créteil 94000, France.
4
INSERM U955 eq07, Recherche Translationnelle en oncogenèse génitale, Créteil 94000, France.
5
Assistance publique-hopitaux de Paris, Groupe Cochin, Laboratoire Pharmacologie Toxicologie, F-75004 Paris, France.
6
Inserm UMR 1085 Irset, Exposure Assessment and Epidemiological Research on Environment, Reproduction and Development, F-35000 Rennes, France.
7
Inserm UMR 1085 Irset, Exposure Assessment and Epidemiological Research on Environment, Reproduction and Development, F-35000 Rennes, France; Université de Rennes I, F-35043 Rennes, France.; Centre Hospitalo-Universitaire de Rennes, Service de Santé Publique et d'Epidémiologie, F-35033 Rennes, France.

Abstract

BACKGROUND:

Glycol ethers (GEs) are oxygenated solvents widely found in occupational and consumer water-based products. Some of them are well-known reproductive and developmental toxicants.

OBJECTIVES:

To study the variations in circulating sex steroid hormones, measured in cord blood, according to biomarkers of prenatal GE exposure.

METHODS:

The study population comes from the PELAGIE mother-child cohort, which enrolled pregnant women from Brittany (France, 2002-2006). Maternal urine samples were collected from a random subcohort (n = 338) before 19 weeks' gestation, from which we measured 8 alkoxycarboxylic metabolites of GEs. We subsequently measured 13 sex steroid hormones and sex hormone-binding globulin (SHBG) in cord blood samples. Linear regressions adjusted for potential confounders were used, and nonlinear dose-response associations were investigated.

RESULTS:

The detection rates of GE metabolites ranged from 4% to 98%; only the 5 most detected (>20%) metabolites were investigated further. Phenoxyacetic acid (detection rate > 95%) was associated with lower levels of SHBG and various steroids (17-alpha-hydroxy-Pregnenolone, delta-5-androstenediol, and dehydroepiandrosterone) among boys and higher SHBG and 16-alpha-hydroxy-dehydroepiandrosterone levels among girls. The two other highly detected metabolites, methoxyetoxyacetic acid and butoxyacetic acid, were associated with variations in estradiol. Butoxyacetic acid was associated with higher delta-5-androstenediol levels while detectable levels of methoxyacetic acid were associated with lower levels of this hormone.

CONCLUSION:

Our study suggests that prenatal exposure to GE may affect endocrine response patterns, estimated by determining blood levels of sex steroid hormones in newborns. These results raise questions about the potential role of these changes in the pathways between prenatal GE exposure and previously reported adverse developmental outcomes, including impaired neurocognitive performance.

KEYWORDS:

Birth cohort; Glycol ethers; Solvent; Steroid hormones

PMID:
29421409
DOI:
10.1016/j.envint.2018.01.013
[Indexed for MEDLINE]

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