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Elife. 2018 Feb 8;7. pii: e32402. doi: 10.7554/eLife.32402.

Challenges in validating candidate therapeutic targets in cancer.

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Calico Life Sciences, South San Francisco, United States.
Memorial Sloan Kettering Cancer Center, New York, United States.
Salk Institute for Biological Studies, La Jolla, United States.


More than 30 published articles have suggested that a protein kinase called MELK is an attractive therapeutic target in human cancer, but three recent reports describe compelling evidence that it is not. These reports highlight the caveats associated with some of the research tools that are commonly used to validate candidate therapeutic targets in cancer research.


cancer biology; melk; protein kinase; replication; reproducibility; scientific publishing

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