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Arch Womens Ment Health. 2018 Aug;21(4):465-469. doi: 10.1007/s00737-018-0816-3. Epub 2018 Feb 7.

Anti-NMDA receptor encephalitis presenting as postpartum psychosis-a clinical description and review.

Author information

1
Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore, 560029, India.
2
Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore, 560029, India. docharisht@gmail.com.
3
Department of Neurology, National Institute of Mental Health and Neuro Sciences, Bangalore, 560029, India.
4
Department of Neuropathology, National Institute of Mental Health and Neuro Sciences, Bangalore, 560029, India.
5
Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neuro Sciences, Bangalore, 560029, India.

Abstract

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is increasingly being recognised to be associated with protean neuropsychiatric manifestations. Anti-NMDAR encephalitis is considered to be the most common amongst the autoimmune-mediated encephalitic disorders. It is caused by the autoantibodies against GluN1 subunits of N-methyl-D-aspartate (NMDA) receptor and manifests with prominent psychiatric symptoms, especially during the initial phase of illness. Literature anti-NMDAR encephalitis presenting with postpartum psychosis is scant. In this report, we present a 28-year-old lady with postpartum psychosis as presenting manifestation of anti-NMDAR encephalitis and discuss the neuropsychiatric manifestations of this emerging entity.

KEYWORDS:

Autoimmune encephalitis; NMDA receptor; NMDAR; Postpartum; Psychosis

PMID:
29417305
DOI:
10.1007/s00737-018-0816-3

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