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Front Immunol. 2018 Jan 24;9:5. doi: 10.3389/fimmu.2018.00005. eCollection 2018.

Nutrients Mediate Intestinal Bacteria-Mucosal Immune Crosstalk.

Ma N1, Guo P1, Zhang J1,2, He T1, Kim SW3, Zhang G4, Ma X1,5,6.

Author information

1
State Key Laboratory of Animal Nutrition, Department of Animal Nutrition and Feed Science, China Agricultural University, Beijing, China.
2
Animal Husbandry and Veterinary Department, Beijing Vocational College of Agriculture, Beijing, China.
3
Department of Animal Science, North Carolina State University, Raleigh, NC, United States.
4
Department of Animal Science, Oklahoma State University, Stillwater, OK, United States.
5
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.
6
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, United States.

Abstract

The intestine is the shared site of nutrient digestion, microbiota colonization and immune cell location and this geographic proximity contributes to a large extent to their interaction. The onset and development of a great many diseases, such as inflammatory bowel disease and metabolic syndrome, will be caused due to the imbalance of body immune. As competent assistants, the intestinal bacteria are also critical in disease prevention and control. Moreover, the gut commensal bacteria are essential for development and normal operation of immune system and the pathogens are also closely bound up with physiological disorders and diseases mediated by immune imbalance. Understanding how our diet and nutrient affect bacterial composition and dynamic function, and the innate and adaptive status of our immune system, represents not only a research need but also an opportunity or challenge to improve health. Herein, this review focuses on the recent discoveries about intestinal bacteria-immune crosstalk and nutritional regulation on their interplay, with an aim to provide novel insights that can aid in understanding their interactions.

KEYWORDS:

bacteria; crosstalk; intestine; mucosal immunity; nutrients

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