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BMC Cancer. 2018 Feb 7;18(1):161. doi: 10.1186/s12885-018-4080-8.

Trends in molecular subtypes of breast cancer: description of incidence rates between 2007 and 2012 from three French registries.

Author information

1
Département d'oncologie chirurgicale, Georges-François Leclerc Cancer Centre, UNICANCER, 1 rue du Professeur Marion, 21000, Dijon, France. marion.cortet@chu-lyon.fr.
2
Breast and Gynaecologic Cancer Registry of Côte d'Or, Georges-François Leclerc Cancer Centre, UNICANCER, 1 rue du Professeur Marion, 21000, Dijon, France. marion.cortet@chu-lyon.fr.
3
Breast and Gynaecologic Cancer Registry of Côte d'Or, Georges-François Leclerc Cancer Centre, UNICANCER, 1 rue du Professeur Marion, 21000, Dijon, France.
4
Registre des Cancers de Loire-Atlantique, Centre Hospitalier Universitaire de Nantes, 50 route de Saint Sébastien, 44093, Nantes, France.
5
Registre des Cancers de la Manche, Centre Hospitalier du Cotentin, 46 rue du Val de Saire, 50102, Cherbourg, France.
6
Département de pathologie, Georges-François Leclerc Cancer Centre, UNICANCER, 1 rue du Professeur Marion, 21000, Dijon, France.
7
Département d'oncologie chirurgicale, Georges-François Leclerc Cancer Centre, UNICANCER, 1 rue du Professeur Marion, 21000, Dijon, France.
8
Centre for Research in Epidemiology and Population Health (CESP), "Health across Generations" Team, Gustave Roussy, Inserm U1018, Villejuif, France.

Abstract

BACKGROUND:

The incidence and incidence trends of breast cancer according to molecular subtype are unknown at a population level in France. The registry data enables this study and may give this information, that is crucial to describe and understand breast cancer epidemiology.

METHODS:

We estimated the incidence rates of breast cancer for each molecular subtype using data from three cancer registries in France for the period from 2007 to 2012. Molecular subtypes were defined with immunohistochemical data. Poisson models were estimated to modelize the course of breast cancer incidence and to test the trends.

RESULTS:

The study included 12,040 patients diagnosed between 2007 and 2012 in the three administrative areas covered by the registries. There was no significant trends in the proportion of each molecular subtype year by year. The age distribution of incident cases was different depending on the molecular subtypes (p < 0.001). The course of incidence between 2007 and 2012 was also different depending on molecular subtype according to the multivariate Poisson model (p < 0.001).

CONCLUSION:

The description of incident cases of breast cancer according to molecular subtype at a population level showed differences in trends. The trends in incidence differed according to molecular subtype, and this should improve our understanding of overall changes in incidence. This analysis is important to plan screening and treatment resources at a population level.

KEYWORDS:

Breast cancer; Incidence; Population data

PMID:
29415671
PMCID:
PMC5804056
DOI:
10.1186/s12885-018-4080-8
[Indexed for MEDLINE]
Free PMC Article

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