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Expert Rev Anti Infect Ther. 2018 Mar;16(3):243-254. doi: 10.1080/14787210.2018.1438265. Epub 2018 Feb 15.

What we know and what we don't know about perinatal Zika virus infection: a systematic review.

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a Pediatric Infectious Diseases and Immunodeficiencies Unit , Hospital Universitari Vall d'Hebron , Barcelona , Spain.
b Translational Pediatrics and Infectious Diseases, Department of Pediatrics , Complejo Hospitalario Universitario de Santiago de Compostela , Santiago de Compostela , Spain.
c Department of Virology , University College of London Hospitals NHS Foundation Trust , London , UK.
d Department of Neonatology , Hospital Universitari Sant Joan de Déu , Barcelona , Spain.


Zika virus (ZIKV) infection has caused the most challenging worldwide infectious epidemic outbreak in recent months. ZIKV causes microcephaly and other congenital malformations. There is a need to perform updated systematic reviews on ZIKV infection periodically because this epidemic is bringing up new evidence with extraordinary speed. Areas covered: Evidence related to ZIKV infection in the gestational, perinatal, and early infant periods covering epidemiology, virology, pathogenesis, risk factors, time of infection during pregnancy, newborn symptoms, treatment, and vaccines. To this end, a search was performed using terms ['Zika'] AND ['Perinatal Infection'] OR ['Congenital Infection'] in the PubMed® international electronic database. Out of a total of 1,538 articles published until 30 November 2017, we finally assessed 106 articles articles that were relevant to the research areas included in this study. Expert commentary: ZIKV is a new teratogenic/neurotropic virus affecting fetuses. Many challenges are still far from being solved regarding the epidemiology, case definition, clinical and laboratory diagnosis, and preventive measures. An approach using 'omics' and new biomarkers for diagnosis, and a ZIKV-vaccine for treatment, might finally give us the tools to solve these challenges.


Arbovirus infection; Zika virus; maternal-fetal infection transmission; teratogen

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