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Viruses. 2018 Feb 6;10(2). pii: E64. doi: 10.3390/v10020064.

The Magistral Phage.

Author information

1
Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Bruynstraat 1, 1120 Brussel, Belgium. jean-paul.pirnay@mil.be.
2
Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Bruynstraat 1, 1120 Brussel, Belgium. gilbert.verbeken@mil.be.
3
Bacterial Diseases, Unit Antibiotic Resistance, Scientific Institute of Public Health, Rue Engelandstraat 642, 1180 Brussel, Belgium. pieterjan.ceyssens@wiv-isp.be.
4
Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, O&N2, Herestraat 49, Box 521, 3000 Leuven, Belgium. isabelle.huys@pharm.kuleuven.be.
5
Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Bruynstraat 1, 1120 Brussel, Belgium. danielmarie.devos@mil.be.
6
Federal Agency for Medicines and Health Products, Place Victor Horta 40/40, 1060 Brussels, Belgium. charlotte.ameloot@fagg-afmps.be.
7
Federal Agency for Medicines and Health Products, Place Victor Horta 40/40, 1060 Brussels, Belgium. alan.fauconnier@invivo.be.
8
Culture In Vivo ASBL, rue du Progrès, 4, boîte 7, 1400 Nivelles, Belgium. alan.fauconnier@invivo.be.

Abstract

Since time immemorial, phages-the viral parasites of bacteria-have been protecting Earth's biosphere against bacterial overgrowth. Today, phages could help address the antibiotic resistance crisis that affects all of society. The greatest hurdle to the introduction of phage therapy in Western medicine is the lack of an appropriate legal and regulatory framework. Belgium is now implementing a pragmatic phage therapy framework that centers on the magistral preparation (compounding pharmacy in the US) of tailor-made phage medicines.

KEYWORDS:

antibiotic; antimicrobial resistance; compounding pharmacy; magistral preparation; personalized medicine; phage therapy; regulatory framework

PMID:
29415431
PMCID:
PMC5850371
DOI:
10.3390/v10020064
[Indexed for MEDLINE]
Free PMC Article

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