Format

Send to

Choose Destination
Nutrients. 2018 Feb 7;10(2). pii: E184. doi: 10.3390/nu10020184.

Vitamin D-Binding Protein Polymorphisms, 25-Hydroxyvitamin D, Sunshine and Multiple Sclerosis.

Author information

1
Los Angeles Medical Center, Neurology Department, Southern California Permanente Medical Group, 1505 N Edgemont Street, Los Angeles, CA 90027, USA. annette.m.langer-gould@kp.org.
2
College of Medicine, Biology & Environment, Australian National University, Canberra, ACT 2000, Australia. robyn.lucas@anu.edu.au.
3
Department of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Avenue, Pasadena, CA 91101, USA. anny.h.xiang@kp.org.
4
Department of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Avenue, Pasadena, CA 91101, USA. jun.x.wu@kp.org.
5
Department of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Avenue, Pasadena, CA 91101, USA. lie.h.chen@kp.org.
6
Department of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Avenue, Pasadena, CA 91101, USA. edlin.g.gonzales@kp.org.
7
Department of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Avenue, Pasadena, CA 91101, USA. samanthaha@pcom.edu.
8
Philadelphia College of Osteopathic Medicine, 4000 Presidential Blvd., Apt. 819, Philadelphia, PA 19131, USA. samanthaha@pcom.edu.
9
Department of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Avenue, Pasadena, CA 91101, USA. jessica.b.smith@kp.org.
10
QB3 Genetic Epidemiology and Genomics Lab, School of Public Health, University of California Berkeley, 209 Hildebrand Hall, Berkeley, CA 94720, USA. hquach@berkeley.ed.
11
QB3 Genetic Epidemiology and Genomics Lab, School of Public Health, University of California Berkeley, 209 Hildebrand Hall, Berkeley, CA 94720, USA. lbarcellos@berkeley.edu.

Abstract

Blacks have different dominant polymorphisms in the vitamin D-binding protein (DBP) gene that result in higher bioavailable vitamin D than whites. This study tested whether the lack of association between 25-hydroxyvitamin D (25OHD) and multiple sclerosis (MS) risk in blacks and Hispanics is due to differences in these common polymorphisms (rs7041, rs4588). We recruited incident MS cases and controls (blacks 116 cases/131 controls; Hispanics 183/197; whites 247/267) from Kaiser Permanente Southern California. AA is the dominant rs7041 genotype in blacks (70.0%) whereas C is the dominant allele in whites (79.0% AC/CC) and Hispanics (77.1%). Higher 25OHD levels were associated with a lower risk of MS in whites who carried at least one copy of the C allele but not AA carriers. No association was found in Hispanics or blacks regardless of genotype. Higher ultraviolet radiation exposure was associated with a lower risk of MS in blacks (OR = 0.06), Hispanics and whites who carried at least one copy of the C allele but not in others. Racial/ethnic variations in bioavailable vitamin D do not explain the lack of association between 25OHD and MS in blacks and Hispanics. These findings further challenge the biological plausibility of vitamin D deficiency as causal for MS.

KEYWORDS:

Hispanics; blacks; multiple sclerosis; polymorphisms; vitamin D

PMID:
29414925
PMCID:
PMC5852760
DOI:
10.3390/nu10020184
[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

Annette Langer-Gould is site principal investigator for two industry-sponsored phase 3 clinical trials (Biogen Idec; Hoffman-LaRoche) and was site PI for one industry-sponsored observation study (Biogen Idec). She receives grant support from the National Institutes of Health, NINDS, PCORI and the National MS Society. Robyn M. Lucas receives grant support from Cancer Australia and the National Health and Medical Research Council of Australia. Lie H. Chen declares no conflict of interest. Jun Wu, Edlin Gonzales, Samantha Haraszti, Jessica B. Smith, Anny H. Xiang, Hong Quach and Lisa F. Barcellos declares no conflict of interest. The funding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center