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Adv Drug Deliv Rev. 2018 Apr;129:37-53. doi: 10.1016/j.addr.2018.01.020. Epub 2018 Feb 4.

Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery.

Author information

1
Section - Targeted Therapeutics, Department of Biomaterials Science and Technology, University of Twente, Enschede, The Netherlands.
2
Section - Targeted Therapeutics, Department of Biomaterials Science and Technology, University of Twente, Enschede, The Netherlands; Department of Pharmaceutics, Utrecht University, Utrecht, The Netherlands.
3
Section - Targeted Therapeutics, Department of Biomaterials Science and Technology, University of Twente, Enschede, The Netherlands; ScarTec Therapeutics BV, Enschede, The Netherlands. Electronic address: j.prakash@utwente.nl.

Abstract

Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well. Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which are regarded as wounds that do not heal. Integrins are heterodimeric surface receptors which control various physiological cellular functions. Additionally, integrins also sense ECM-induced extracellular changes during pathological events, leading to cellular responses, which influence ECM remodeling. The purpose and scope of this review is to introduce integrins as key targets for therapeutics and drug delivery within the scope of wound healing, fibrosis and the tumor stroma. This review provides a general introduction to the biology of integrins including their types, ligands, means of signaling and interaction with growth factor receptors. Furthermore, we highlight integrins as key targets for therapeutics and drug delivery, based on their biological role, expression pattern within human tissues and at cellular level. Next, therapeutic approaches targeting integrins, with a focus on clinical studies, and targeted drug delivery strategies based on ligands are described.

PMID:
29414674
DOI:
10.1016/j.addr.2018.01.020
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