Format

Send to

Choose Destination
Epilepsy Behav. 2018 Mar;80:144-151. doi: 10.1016/j.yebeh.2017.12.040. Epub 2018 Feb 2.

Effect of traditional medicine brahmi vati and bacoside A-rich fraction of Bacopa monnieri on acute pentylenetetrzole-induced seizures, amphetamine-induced model of schizophrenia, and scopolamine-induced memory loss in laboratory animals.

Author information

1
School of Pharmaceutical Sciences, IFTM University, Moradabad 244102, India. Electronic address: amrita_azam@rediffmail.com.
2
School of Pharmaceutical Sciences, IFTM University, Moradabad 244102, India.
3
Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India.

Abstract

OBJECTIVE:

Brahmi vati (BV) is an Ayurvedic polyherbal formulation used since ancient times and has been prescribed in seizures associated with schizophrenia and related memory loss by Ayurvedic practitioners in India. The aim of the study was to investigate these claims by evaluation of anticonvulsant, antischizophreniac, and memory-enhancing activities. Antioxidant condition of brain was determined by malondialdehyde (MDA) and reduced glutathione (GSH) levels estimations. Acetylcholinesterase (AChE) was quantitatively estimated in the brain tissue.

METHODS:

Brahmi vati was prepared in-house by strictly following the traditional Ayurvedic formula. Bacoside A rich fraction (BA) of Bacopa monnieri was prepared by extraction and fractionation. It was than standardized by High Performance Liquid Chromatography (HPLC) and given in the dose of 32.5mg/kg body weight to the different groups of animals for 7days. On the seventh day, activities were performed adopting standard procedures.

KEY FINDINGS:

Brahmi vati showed significant anticonvulsant, memory-enhancing and antischizophrenia activities, when compared with the control groups and BA. It cause significantly higher brain glutathione levels. Acetylcholinesterase activity was found to be significantly low in BV-treated group.

CONCLUSION:

The finding of the present study suggests that BV may be used to treat seizures associated with schizophrenia and related memory loss.

KEYWORDS:

Acetylcholinesterase; Ayurvedic; Brahmi vati; Polyherbo-mineral; Schizophrenia

PMID:
29414544
DOI:
10.1016/j.yebeh.2017.12.040
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center