Format

Send to

Choose Destination
Cardiovasc Pathol. 2018 Mar - Apr;33:27-31. doi: 10.1016/j.carpath.2017.12.001. Epub 2017 Dec 28.

Characteristics, survival and incidence rates and trends of primary cardiac malignancies in the United States.

Author information

1
Faculty of Medicine, Ain Shams University, Cairo, Egypt.
2
Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: Abdelrahman.abushouk@med.asu.edu.eg.
3
Pharmacology Department, Suez Canal University, Ismailia, Egypt; Department of Ophthalmology and Micro-Technology, Yokohama City University, Yokohama, Japan.

Abstract

BACKGROUND:

The available literature on the incidence, management and prognosis of primary malignant cardiac tumors [PMCTs] is limited to single-center studies, prone to small sample size and referral bias. We used data from the Surveillance, Epidemiology, and End Results [SEER]-18 registry (between 2000 and 2014) to investigate the distribution, incidence trends and the survival rates of PMCTs.

METHODS:

We used SEER*Stat (version 8.3.4) and the National Cancer Institute's Joinpoint Regression software (version 4.5.0.1) to calculate the incidence rates and annual percentage changes [APC] of PMCTs, respectively. We later used SPSS software (version 23) to perform Kaplan-Meier survival tests and covariate-adjusted Cox models.

RESULTS:

We identified 497 patients with PMCTs, including angiosarcomas (27.3%) and Non-Hodgkin's lymphomas [NHL] (26.9%). Unlike the incidence rate of NHL (0.108 per 106 person-years) that increased significantly (APC=3.56%, 95% CI, [1.445 to 5.725], P=.003) over the study period, we detected no significant change (APC=1.73%, 95% CI [-3.354 to 7.081], P=.483) in the incidence of cardiac angiosarcomas (0.107 per 106 person-years). Moreover, our analysis showed that the overall survival of NHL is significantly better than angiosarcomas (P<.001). In addition, surgical treatment was associated with a significant improvement (P=.027) in the overall survival of PMCTs.

CONCLUSION:

Our analysis showed a significant increase in the incidence of cardiac-NHL over the past 14 years with a significantly better survival than angiosarcomas. To further characterize these rare tumors, future studies should report data on the medical history and diagnostic and treatment modalities in these patients.

KEYWORDS:

Epidemiology; Heart; Surveillance; Tumors

PMID:
29414429
DOI:
10.1016/j.carpath.2017.12.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center