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Annu Rev Med. 2018 Jan 29;69:379-394. doi: 10.1146/annurev-med-052716-030320.

New Molecular Diagnostic Approaches to Bacterial Infections and Antibacterial Resistance.

Author information

1
Division of Infectious Diseases & International Health, Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710.
2
Emergency Medicine Service, Durham Veterans Affairs Medical Center, Durham, North Carolina 27705.
3
Medical and Research Services, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106.
4
Departments of Medicine, Pharmacology, Molecular Biology and Microbiology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.
5
Duke Clinical Research Institute, Durham, North Carolina 27705; email: vance.fowler@duke.edu.

Abstract

Recent advances in the field of infectious disease diagnostics have given rise to a number of host- and pathogen-centered diagnostic approaches. Most diagnostic approaches in contemporary infectious disease focus on pathogen detection and characterization. Host-focused diagnostics have recently emerged and are based on detecting the activation of biological pathways that are highly specific to the type of infecting pathogen (e.g., viral, bacterial, protozoan, fungal). Although this progress is encouraging, it is unlikely that any single diagnostic platform will fully address the clinician's need for actionable data with short turnaround times in all settings.

KEYWORDS:

gene expression profiling; host response diagnostics; host-pathogen interactions; infectious diseases diagnostics; nucleic acid biomarkers; point-of-care testing

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