Format

Send to

Choose Destination
Eur J Cancer. 2018 Mar;91:107-115. doi: 10.1016/j.ejca.2017.12.017.

Fatty acid profile in peri-prostatic adipose tissue and prostate cancer aggressiveness in African-Caribbean and Caucasian patients.

Author information

1
Inserm UMR1069 "Nutrition, Croissance et Cancer" Université François Rabelais, Faculté de Médecine, 10 Bd Tonnellé, 37032 Tours, France.
2
Inserm UMR1069 "Nutrition, Croissance et Cancer" Université François Rabelais, Faculté de Médecine, 10 Bd Tonnellé, 37032 Tours, France; CHRU Bretonneau, Department of Pathology, Tours, France; CHRU Bretonneau, Department of Urology, Tours, France.
3
CHRU Tours, Clinical Investigation Center - INSERM 1415, Tours, France.
4
CHU Pointe à Pitre, Department of Urology, Guadeloupe, France; Inserm UMR1085 - IRSET, Rennes, France.
5
Inserm UMR1085 - IRSET, Rennes, France.
6
CHRU Bretonneau, Department of Pathology, Tours, France; CHRU Bretonneau, Department of Urology, Tours, France.
7
CHU Rennes, Department of Pathology, Rennes, France; CHU Rennes, Department of Urology, Rennes, France.
8
CHU Angers, Department of Urology, Angers, France.
9
CHU Brest, Department of Pathology, Brest, France; CHU Brest, Department of Urology, Brest, France.
10
CHU Nantes, Department of Pathology, Nantes, France; CHU Nantes, Department of Urology, Nantes, France.
11
Inserm UMR1069 "Nutrition, Croissance et Cancer" Université François Rabelais, Faculté de Médecine, 10 Bd Tonnellé, 37032 Tours, France; CHRU Bretonneau, Department of Pathology, Tours, France; CHRU Bretonneau, Department of Urology, Tours, France. Electronic address: gaelle.fromont-hankard@univ-tours.fr.

Abstract

BACKGROUND:

Genetic and nutritional factors have been linked to the risk of aggressive prostate cancer (PCa). The fatty acid (FA) composition of peri-prostatic adipose tissue (PPAT), which reflects the past FA intake, is potentially involved in PCa progression. We analysed the FA composition of PPAT, in correlation with the ethno-geographical origin of the patients and markers of tumour aggressiveness.

METHODS:

From a cohort of 1000 men treated for PCa by radical prostatectomy, FA composition of PPAT was analysed in 156 patients (106 Caucasians and 50 African-Caribbeans), 78 with an indolent tumour (ISUP group 1 + pT2 + PSA <10 ng/mL) and 78 with an aggressive tumour (ISUP group 4-5 + pT3). The effect of FA extracted from PPAT on in-vitro migration of PCa cells DU145 was studied in 72 patients, 36 Caucasians, and 36 African-Caribbeans.

RESULTS:

FA composition differed according to the ethno-geographical origin. Linoleic acid, an essential n-6 FA, was 2-fold higher in African-Caribbeans compared with Caucasian patients, regardless of disease aggressiveness. In African-Caribbeans, the FA profile associated with PCa aggressiveness was characterised by low level of linoleic acid along with high levels of saturates. In Caucasians, a weak and negative association was observed between eicosapentaenoic acid level (an n-3 FA) and disease aggressiveness. In-vitro migration of PCa cells using PPAT from African-Caribbean patients was associated with lower content of linoleic acid.

CONCLUSION:

These results highlight an important ethno-geographical variation of PPAT, in both their FA content and association with tumour aggressiveness.

KEYWORDS:

Cancer aggressiveness; Fatty acids; Linoleic acid; Peri-prostatic adipose tissue; Prostate cancer

PMID:
29413967
DOI:
10.1016/j.ejca.2017.12.017
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center