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Sleep Med Clin. 2018 Mar;13(1):39-50. doi: 10.1016/j.jsmc.2017.09.004. Epub 2017 Nov 27.

Circadian Rhythm Sleep-Wake Disorders in Older Adults.

Author information

1
Department of Neurology, Dankook University College of Medicine, Dankook University Hospital, Manghyang-ro 201, Dongnam-gu, Cheonan, Chungnam 31116, Republic of Korea; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, 221 Longwood Avenue, BLI438, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
2
Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, 221 Longwood Avenue, BLI438, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: jduffy@research.bwh.harvard.edu.

Abstract

The timing, duration, and consolidation of sleep result from the interaction of the circadian timing system with a sleep-wake homeostatic process. When aligned and functioning optimally, this allows wakefulness throughout the day and a long consolidated sleep episode at night. Mismatch between the desired timing of sleep and the ability to fall and remain asleep is a hallmark of the circadian rhythm sleep-wake disorders. This article discusses changes in circadian regulation of sleep with aging; how age influences the prevalence, diagnosis, and treatment of circadian rhythm sleep-wake disorders; and how neurologic diseases in older patients affect circadian rhythms and sleep.

KEYWORDS:

Advanced sleep phase; Alzheimer disease; Circadian rhythm disruption; Circadian rhythm sleep disorders; Delayed sleep phase; Light therapy; Melatonin

PMID:
29412982
DOI:
10.1016/j.jsmc.2017.09.004
[Indexed for MEDLINE]

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