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Nat Prod Res. 2018 Feb 7:1-8. doi: 10.1080/14786419.2018.1434636. [Epub ahead of print]

MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053.

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1
a Fundación MEDINA , Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía , Granada , Spain.

Abstract

A new medermycin derivative, MDN-0171 (1), and two known structurally related compounds, medermycin (2) and antibiotic G15-F (3) were isolated from the acetone extract of culture broths of the marine-derived Streptomyces albolongus strain CA-186053. Their structures were determined using a combination of spectroscopic techniques, including 1D and 2D NMR and electrospray-time of flight mass spectrometry (ESI-TOF MS). Compounds 2 and 3 accounted for the antimicrobial activity (against methicillin-resistant Staphylococcus aureus and Escherichia coli) previously detected in the crude extract of this actinomycete.

KEYWORDS:

Medermycin; Streptomyces albolongus; marine natural products; pyranonaphthoquinone; structural elucidation

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