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J Infect Dis. 2018 Mar 13;217(7):1055-1059. doi: 10.1093/infdis/jix653.

Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine.

Author information

1
Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora.
2
Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora.
3
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta and Hope Clinic, Emory Vaccine Center, Decatur, Georgia.
4
Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora.

Abstract

We studied the relationship between varicella-zoster virus (VZV) DNAemia and development of VZV-specific immunity after administration of live-attenuated zoster vaccine. VZV-DNAemia, detected by polymerase chain reaction (PCR), and VZV-specific effector (Teff) and memory (Tmem) T cells, was measured in 67 vaccinees. PCR was positive in 56% (9 direct, 28 nested) on day 1 and in 16% (1 direct, 10 nested) on day 14. Teff progressively increased in direct-PCR-positive vaccinees up to day 30, but Tmem did not. Conversely, Tmem, but not Teff, increased in direct-PCR-negative vaccinees on day 7. The kinetics of these immune responses and VZV DNAemia suggested that direct-PCR sample positive represented viremia.

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