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Brain. 2018 Mar 1;141(3):916-926. doi: 10.1093/brain/awx366.

MicroRNA132 associated multimodal neuroimaging patterns in unmedicated major depressive disorder.

Qi S1,2, Yang X3,4, Zhao L3,4, Calhoun VD5,6,7,8, Perrone-Bizzozero N7,8, Liu S1, Jiang R1,2, Jiang T1,2,9, Sui J1,2,5,9, Ma X3,4.

Author information

1
Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, China.
2
University of Chinese Academy of Sciences, China.
3
Psychiatric Laboratory and Mental Health Center, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, China.
4
Huaxi Brain Research Center, West China Hospital of Sichuan University, China.
5
The Mind Research Network, Albuquerque, NM, USA.
6
Department of Electronical and Computer Engineering, University of New Mexico, USA.
7
Department of Neurosciences and Psychiatry, University of New Mexico, USA.
8
Department of Psychiatry, Yale University, CT, USA.
9
CAS Centre for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, China.

Abstract

There is compelling evidence that epigenetic factors contribute to the manifestation of depression, in which microRNA132 (miR-132) is suggested to play a pivotal role in the pathogenesis and neuronal mechanisms underlying the symptoms of depression. Additionally, several depression-associated genes [MECP2, ARHGAP32 (p250GAP), CREB, and period genes] were experimentally validated as miR-132 targets. However, most studies regarding miR-132 in major depressive disorder are based on post-mortem, animal models or genetic comparisons. This work will be the first attempt to investigate how miR-132 dysregulation may impact covariation of multimodal brain imaging data in 81 unmedicated major depressive patients and 123 demographically-matched healthy controls, as well as in a medication-naïve subset of major depressive patients. MiR-132 values in blood (patients > controls) was used as a prior reference to guide fusion of three MRI features: fractional amplitude of low frequency fluctuations, grey matter volume, and fractional anisotropy. The multimodal components correlated with miR-132 also show significant group difference in loadings. Results indicate that (i) higher miR-132 levels in major depressive disorder are associated with both lower fractional amplitude of low frequency fluctuations and lower grey matter volume in fronto-limbic network; and (ii) the identified brain regions linked with increased miR-132 levels were also associated with poorer cognitive performance in attention and executive function. Using a data-driven, supervised-learning method, we determined that miR-132 dysregulation in major depressive disorder is associated with multi-facets of brain function and structure in fronto-limbic network (the key network for emotional regulation and memory), which deepens our understanding of how miR-132 dysregulation in major depressive disorders contribute to the loss of specific brain areas and is linked to relevant cognitive impairments.

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