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J Allergy Clin Immunol Pract. 2018 May - Jun;6(3):776-781. doi: 10.1016/j.jaip.2018.01.025. Epub 2018 Feb 3.

Inhaled Corticosteroids Safety and Adverse Effects in Patients with Asthma.

Author information

1
Department of Biomedical Sciences, Humanitas University, Milano, Italy; Personalized Medicine, Asthma and Allergy Clinic, Humanitas Research Hospital, Milano, Italy.
2
Personalized Medicine, Asthma and Allergy Clinic, Humanitas Research Hospital, Milano, Italy; Pediatrics, Allergy and Respiratory Disease, Mater Dei Hospital, Belo Horizonte, Brazil.
3
Personalized Medicine, Asthma and Allergy Clinic, Humanitas Research Hospital, Milano, Italy; Allergy and Respiratory Diseases, DIMI Department of Internal Medicine, University of Genoa, Genoa, Italy.
4
Personalized Medicine, Asthma and Allergy Clinic, Humanitas Research Hospital, Milano, Italy.
5
Department of Otolaringology, Humanitas Clinical and Research Center, Milano, Italy.
6
Allergy and Respiratory Diseases, DIMI Department of Internal Medicine, University of Genoa, Genoa, Italy.
7
Department of Biomedical Sciences, Humanitas University, Milano, Italy; Personalized Medicine, Asthma and Allergy Clinic, Humanitas Research Hospital, Milano, Italy. Electronic address: giorgio_walter.canonica@hunimed.eu.

Abstract

Asthma is a common inflammatory airway disease for which the most commonly used controller medications are inhaled corticosteroids (ICS). Asthma control is difficult to achieve in individuals with severe asthma, which comprise 5% to 10% of individuals with asthma, even with high doses of ICS and other anti-inflammatory drugs. In this clinical context, the adverse effects of ICS (including hypothalamic-pituitary-adrenal axis suppression, reduction in growth velocity, osteoporosis, diabetes, and respiratory infections) become more probable and impacting on the quality of life of severe asthmatics. We here summarize the evidence of ICS-related adverse effects, particularly in patients with asthma. The possibility of using biologic agents earlier for severe asthma has the potential to prevent or reduce the occurrence of corticosteroid-related adverse effects, and also reduce corticosteroid-related costs.

KEYWORDS:

Asthma; Biologics; Inhaled corticosteroids; Safety; Side effects

PMID:
29408385
DOI:
10.1016/j.jaip.2018.01.025

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