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Neurobiol Aging. 2018 May;65:18-40. doi: 10.1016/j.neurobiolaging.2017.12.023. Epub 2017 Dec 30.

Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study.

Author information

1
Department of Physiology and Pharmacology "Vittorio Erspamer", University of Rome "La Sapienza", Rome, Italy; Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy. Electronic address: claudio.babiloni@uniroma1.it.
2
Department of Integrated Imaging, IRCCS SDN, Naples, Italy.
3
Department of Physiology and Pharmacology "Vittorio Erspamer", University of Rome "La Sapienza", Rome, Italy; Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy.
4
Department of Physiology and Pharmacology "Vittorio Erspamer", University of Rome "La Sapienza", Rome, Italy.
5
Department of Integrated Imaging, IRCCS SDN, Naples, Italy; Department of Motor Sciences and Healthiness, University of Naples Parthenope, Naples, Italy.
6
Department of Neurology, IRCCS Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Enna, Italy.
7
Clinical Neurology, Department of Neuroscience (DiNOGMI), University of Genoa and IRCCS AOU S Martino-IST, Genoa, Italy.
8
Department of Old Age Psychiatry, King's College University, London, UK.
9
Department of Neuroscience, Mental Health and Sensory Organs, University of Rome "La Sapienza", Rome, Italy.
10
Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d'Annunzio of Chieti-Pescara, Chieti, Italy.
11
Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy.
12
Universitätsspital Basel, Abteilung Neurophysiologie, Basel, Switzerland.
13
Department of Neurology and Psychiatry and Faculty of Medicine, Johannes Kepler University Linz, General Hospital of the City of Linz, Linz, Austria.
14
AIT Austrian Institute of Technology GmbH, Vienna, Austria.
15
Hospital San Raffaele of Cassino, Cassino, Italy.
16
Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
17
Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.
18
Department of Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy.
19
Department of Biophysics, Istanbul Medipol University, Istanbul, Turkey.
20
Department of Neurology, University of Istanbul-Medipol, Istanbul, Turkey.
21
IBG, Departments of Neurology and Neurosciences, Dokuz Eylül University, Izmir, Turkey.
22
Department of Psychology and Department of Neurosciences, Dokuz Eylül University, Izmir, Turkey.
23
Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
24
Institute of Neuroscience, Newcastle University, Newcastle, UK.
25
Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy; Casa di Cura Privata del Policlinico (CCPP) Milano SpA, Milan, Italy.

Abstract

Previous evidence showed abnormal posterior sources of resting-state delta (<4 Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer's disease with dementia (ADD), Parkinson's disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a "disconnection cortical syndrome", in comparison with PDD and DLB. Resting-state eyes-closed electroencephalographic (rsEEG) rhythms had been collected in 42 ADD, 42 PDD, 34 DLB, and 40 normal healthy older (Nold) participants. Exact low-resolution brain electromagnetic tomography (eLORETA) freeware estimated the functional lagged linear connectivity (LLC) from rsEEG cortical sources in delta, theta, alpha, beta, and gamma bands. The area under receiver operating characteristic (AUROC) curve indexed the classification accuracy between Nold and diseased individuals (only values >0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in the ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD groups. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD versus Nold individuals (0.84) than for DLB versus Nold participants (0.78) and PDD versus Nold participants (0.75). Functional cortical connectivity markers in delta and alpha sources suggest a more compromised neurophysiological reserve in ADD than DLB, at both group and individual levels.

KEYWORDS:

Alzheimer's disease; Dementia; Dementia with Lewy bodies; Functional brain connectivity; Neurodegenerative diseases; Parkinson's disease; Resting-state EEG rhythms

[Indexed for MEDLINE]

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