Send to

Choose Destination
Ann Transl Med. 2018 Jan;6(1):18. doi: 10.21037/atm.2017.11.11.

Peri-procedural antibiotic prophylaxis in ventricular septal defect: a case study to re-visit guidelines.

Author information

Department of Cardiology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Medical Student, University of Tennessee Health Science Center, Memphis, Tennessee, USA.


The current American Heart Association (AHA)/American College of Cardiology (ACC) guidelines do not recommend antibiotic prophylaxis for infective endocarditis (IE) in patients with acyanotic congenital valvular heart disease due to lack of any proven benefit and potential harm associated with antibiotics. As recognized by the guidelines, some acyanotic congenital heart disease, such as ventricular septal defects (VSDs), are associated with a high velocity jet and pose a greater risk of peri-procedural endocarditis. We suggest that an acyanotic congenital heart disease with high velocity jet should be considered for antibiotic prophylaxis for IE.


Ventricular septal defect (VSD); antibiotic prophylaxis; infective endocarditis (IE)

Conflict of interest statement

Conflicts of Interest: This case report was presented at ACC 2016 as a poster.

Supplemental Content

Full text links

Icon for AME Publishing Company Icon for PubMed Central
Loading ...
Support Center