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Eur J Microbiol Immunol (Bp). 2017 Nov 20;7(4):303-309. doi: 10.1556/1886.2017.00033. eCollection 2017 Dec 18.

Toxoplasma Gondii Exposure and Neurological Disorders: An Age- and Gender-Matched Case-Control Pilot Study.

Author information

1
Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Mexico.
2
Institute for Scientific Research "Dr. Roberto Rivera-Damm," Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Mexico.
3
Instituto de Seguridad y Servicios Sociales para los Trabajadores del Estado, Predio Canoas S/N, 34000 Durango, Mexico.
4
Leibniz Institute for Neurobiology, Brenneckestr. 6, 39118 Magdeburg, Germany.
5
Department of Psychiatry and Psychotherapy, Campus Mitte, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
6
Institute for Microbiology and Hygiene, Campus Benjamin Franklin, Charité Medical School, Hindenburgdamm 27, D-12203 Berlin, Germany.
7
Institute of Inflammation and Neurodegeneration, Otto von Guericke University Magdeburg, Magdeburg D-39120, Leipziger Str. 44, Germany.

Abstract

Little is known about the association of Toxoplasma gondii infection and neurological disorders. We performed a case-control study with 344 patients with neurological diseases and 344 neurologically healthy age- and gender-matched subjects. Sera of participants were analyzed for anti-T. gondii IgG and IgM antibodies using commercially available immunoassays. Anti-T. gondii IgG antibodies were detected in 25 (7.3%) cases and in 35 (10.2%) controls (odds ratio [OR] = 0.69; 95% confidence interval [CI]: 0.40-1.18; P = 0.17). Anti-T. gondii IgM antibodies were found in 5 (14.3%) of the 25 IgG seropositive cases and in 13 (37.1°%) of the 35 IgG seropositive controls (P = 0.15). Anti-T. gondii IgG antibodies were found in 8 (3.8%) of 213 female cases and in 23 (10.8%) of 213 female controls (OR = 0.32; 95% CI: 0.14-0.73; P = 0.005); and in 17 (13.0%) of 131 male cases and in 12 (9.2%) of 131 male controls (P = 0.32). No direct association between IgG seropositivity and specific neurological disorders was detected. We found no support for a role of latent T. gondii infection in the risk for neurological disorders in this setting. With respect to specific neurological disorders, further studies using larger patient cohorts will be required.

KEYWORDS:

Mexico; Toxoplasma gondii; case-control study; epidemiology; infection; neurological disorders; seroprevalence

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