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Front Pharmacol. 2018 Jan 17;8:997. doi: 10.3389/fphar.2017.00997. eCollection 2017.

Recent Progress in CFTR Interactome Mapping and Its Importance for Cystic Fibrosis.

Author information

1
Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
2
Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
3
Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.

Abstract

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride channel found in secretory epithelia with a plethora of known interacting proteins. Mutations in the CFTR gene cause cystic fibrosis (CF), a disease that leads to progressive respiratory illness and other complications of phenotypic variance resulting from perturbations of this protein interaction network. Studying the collection of CFTR interacting proteins and the differences between the interactomes of mutant and wild type CFTR provides insight into the molecular machinery of the disease and highlights possible therapeutic targets. This mini review focuses on functional genomics and proteomics approaches used for systematic, high-throughput identification of CFTR-interacting proteins to provide comprehensive insight into CFTR regulation and function.

KEYWORDS:

CFTR interactome; cystic fibrosis; interactome mapping; protein-protein interactions; proteomics

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