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Blood Purif. 2018;45(1-3):95-101. doi: 10.1159/000484922. Epub 2017 Dec 12.

Effect of Sedative-Hypnotic Medicines on Mortality in Peritoneal Dialysis Patients with Sleep Disorders: A Retrospective Cohort Study.

Zhou Y1,2,3, Yin P1,2, Li B1,2,4, Li J1,2, Huang N1,2, Wu H1,2, Ullah H1,2, Yang X1,2, Yu X1,2.

Author information

1
Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
2
Key Laboratory of Nephrology, Ministry of Health and Guangdong Province, Guangzhou, China.
3
Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
4
Clinical Research Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Abstract

BACKGROUND:

Sedative-hypnotic medication is widely used among continuous ambulatory peritoneal dialysis (CAPD) patients with sleep disorders; however, its effect on mortality has rarely been investigated.

METHODS:

Logistic regression was employed to identify factors associated with sedative-hypnotic medication, whose effect on mortality was evaluated by Cox proportional hazards models.

RESULTS:

A total of 146 CAPD patients with sleep disorders were recruited, of which 46 patients (31.5%) used either benzodiazepines or zolpidem. Sedative-hypnotic medication was more frequently used by older patients and those with longer duration of CAPD therapy and there was no significant association between sedative-hypnotic medicines and all-cause mortality after adjusting for age, gender, diabetes, cardiovascular disease, and duration of CAPD.

CONCLUSION:

Sedative-hypnotic medication was more often used by older patients and patients with a longer duration of CAPD. There was no association between these agents and all-cause mortality in CAPD patients with sleep disorders.

KEYWORDS:

End-stage renal disease; Mortality; Peritoneal dialysis; Sedative-hypnotic medicines; Sleep disorders; Uremic complication

PMID:
29402860
DOI:
10.1159/000484922
[Indexed for MEDLINE]

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