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Horm Res Paediatr. 2018;89(2):122-131. doi: 10.1159/000486035. Epub 2018 Jan 18.

Correlation of Insulin-Like Growth Factor-I and -II Concentrations at Birth Measured by Mass Spectrometry and Growth from Birth to Two Months.

Author information

1
Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
2
The National Children's Research Centre, Dublin, Ireland.
3
Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.
4
The Irish Centre for Fetal and Neonatal Translational Research, Cork, Ireland.
5
Department of Obstetrics and Gynaecology, University College Cork, Cork, Ireland.
6
School of Food and Nutritional Science, University College Cork, Cork, Ireland.
7
Department of Clinical Medicine, Trinity College Dublin, Dublin, Ireland.
8
Quest Diagnostics Nichols Institute, San Juan Capistrano, California, USA.
9
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
10
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Abstract

BACKGROUND:

Immunoassays used to measure insulin-like growth factor (IGF)-I and -II concentrations are susceptible to interference from IGF-binding proteins. The aim of this study was to investigate the association of IGF-I and -II concentrations at birth with neonatal anthropometry using a liquid chromatography/mass spectrometry (LCMS) assay.

METHODS:

LCMS was used to measure IGF-I and -II concentrations in umbilical cord blood of term, healthy infants enrolled in the Cork BASELINE Birth Cohort Study. Weight, length, and occipitofrontal head circumference (OFC) were measured at birth and 2 months.

RESULTS:

Cord blood IGF-I and -II concentrations were measured in 1,100 infants. Mean (SD) IGF-I and -II concentrations were 52.5 (23.9) ng/mL and 424.3 (98.2) ng/mL, respectively. IGF-I and -II concentrations at birth were associated (p < 0.05) with weight (R2 = 0.19, R2 = 0.01), length (R2 = 0.07, R2 = 0.004), and OFC (R2 = 0.03, R2 = 0.04) at birth. Low IGF-I concentrations at birth were associated with increases in weight (p < 0.001) and OFC (p < 0.01) Z-scores in the first 2 months.

CONCLUSION:

Using an LCMS assay, we have shown that anthropometric parameters at birth are associated with IGF-I and weakly with IGF-II concentrations. This indicates that, at the time of birth, IGF-I is the more important growth factor for regulating infant growth.

KEYWORDS:

Assay; Growth hormone; IGF-I; IGF-II; Mass spectrometry

PMID:
29402777
DOI:
10.1159/000486035
[Indexed for MEDLINE]

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