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J Agric Food Chem. 2018 Feb 28;66(8):1807-1812. doi: 10.1021/acs.jafc.7b05330. Epub 2018 Feb 13.

New α-Pyridones with Quorum-Sensing Inhibitory Activity from Diversity-Enhanced Extracts of a Streptomyces sp. Derived from Marine Algae.

Author information

1
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, China.
2
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology , Qingdao 266003, China.

Abstract

Four new α-pyrones (1-4) and eight known analogues (5-12) were identified from the secondary metabolites of Streptomyces sp. OUCMDZ-3436 derived from the marine green algae Enteromorpha prolifera. Seven new α-pyridones (14-20) were constructed by diversity-oriented synthesis, which has been an effective approach to expanding the chemical space of natural-product-like compounds. Compounds 16, 17, 19, and 20 were found to have inhibitory effect on the gene expression controlled by quorum sensing in Pseudomonas aeruginosa QSIS-lasI.

KEYWORDS:

Enteromorpha prolifera; QS-inhibition; Streptomyces sp.; diversity-enhanced extracts; pyridone

PMID:
29400957
DOI:
10.1021/acs.jafc.7b05330
[Indexed for MEDLINE]

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