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Chonnam Med J. 2018 Jan;54(1):10-16. doi: 10.4068/cmj.2018.54.1.10. Epub 2018 Jan 25.

Functional Relevance of Macrophage-mediated Inflammation to Cardiac Regeneration.

Kim YS1,2, Ahn Y2,3.

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Biomedical Research Institute, Chonnam National University Hospital, Gwangju, Korea.
Cell Regeneration Research Center, Chonnam National University Hospital, Gwangju, Korea.
Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea.


Cardiovascular disease remains the leading cause of death worldwide and regenerative medicine is a promising therapeutic option for this disease. We have developed various techniques to attenuate the cardiac remodeling and to regenerate cardiovascular systems via stem cell application. Besides cell therapy, we are interested in the modulation of pathological inflammation mediated by macrophages in the damaged heart tissue to arouse endogenous reparative responses with biocompatible small molecules. Certainly, current understanding of mechanisms of tissue regeneration will lead to the development of innovative regenerative medicine for cardiovascular disease.


Cardiovascular Diseases; Inflammation; Macrophages; Regeneration; Stem Cells

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