Format

Send to

Choose Destination
Adv Pharm Bull. 2017 Dec;7(4):651-654. doi: 10.15171/apb.2017.078. Epub 2017 Dec 31.

Role of Essential Oil of Mentha Spicata (Spearmint) in Addressing Reverse Hormonal and Folliculogenesis Disturbances in a Polycystic Ovarian Syndrome in a Rat Model.

Author information

1
Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
2
Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

Purpose: Given the antiandrogenic effects of spearmint, in this study we evaluated the effects of its essential oil on polycystic ovarian syndrome in a rat model. Methods: Female rats were treated as follows: Control, normal rats which received 150 mg/kg spearmint oil or 300 mg/kg spearmint oil, or sesame oil; and PCOS-induced rats which received 150 mg/kg spearmint oil or 300 mg/kg spearmint oil, or sesame oil. Then the animals were killed and the levels of LH, FSH, testosterone and ovarian folliculogenesis were evaluated. Results: Spearmint oil reduced body weight, testosterone level, ovarian cysts and atretic follicles and increased Graafian follicles in PCOS rats. Conclusion: Spearmint has treatment potential on PCOS through inhibition of testosterone and restoration of follicular development in ovarian tissue.

KEYWORDS:

Folliculogenesis; Mentha spicata; PCOS; Rat

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center