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Cytotherapy. 2018 Mar;20(3):461-476. doi: 10.1016/j.jcyt.2017.12.004. Epub 2018 Feb 15.

Proceedings of the signature series event of the international society for cellular therapy: "Advancements in cellular therapies and regenerative medicine in digestive diseases," London, United Kingdom, May 3, 2017.

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Gastroenterology Unit, Department of Medicine, University of Verona and AOUI Borgo Roma, Verona, Italy. Electronic address:
Interdepartmental Division of Critical Care Medicine, Keenan Research Centre for Biomedical Science and St. Michael's Hospital, University of Toronto, Toronto, Canada.
Inflammatory Bowel Disease Center, Department of Gastroenterology and Hepatology, Charité Medical School, Humboldt, University of Berlin, Berlin, Germany.
Laboratory of Gastroenterology, Department of Medicine, University of Pavia, I.R.C.C.S. Policlinico San Matteo Foundation, Pavia, Italy.
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.
Gastrointestinal Immunology Center for the Study of Celiac Disease, Inflammatory Bowel Disease and Food Intolerance, Baronissi Campus, University of Salerno, Salerno, Italy.
University College London Institute of Child Health, Great Ormond Street Hospital, London, United Kingdom.
National Institute for Health Research Birmingham, Birmingham Liver Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom.
Service of Clinical Epidemiology & Biostatistics, I.R.C.C.S. Policlinico San Matteo Foundation, Pavia, Italy.
McEwen Centre for Regenerative Medicine, Toronto General Hospital Research Institute, UHN and Department of Physiology, University of Toronto, Toronto, Canada.
Hannover Medical School, Twincore Centre for Experimental and Clinical Infection Research, Hannover, Germany.
Diabetes Research Institute (SR-DRI), IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
Diabetes Research Institute, Biomedical Engineering, University of Miami Miller School of Medicine, Miami, Florida, USA.
Center for Engineering in Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Department of Biomedical Sciences, Humanitas University, Rozzano, Italy.
Wake Forest University School of Medicine, Winston Salem, North Carolina, USA.


A summary of the First Signature Series Event, "Advancements in Cellular Therapies and Regenerative Medicine for Digestive Diseases," held on May 3, 2017, in London, United Kingdom, is presented. Twelve speakers from three continents covered major topics in the areas of cellular therapy and regenerative medicine applied to liver and gastrointestinal medicine as well as to diabetes mellitus. Highlights from their presentations, together with an overview of the global impact of digestive diseases and a proposal for a shared online collection and data-monitoring platform tool, are included in this proceedings. Although growing evidence demonstrate the feasibility and safety of exploiting cell-based technologies for the treatment of digestive diseases, regulatory and methodological obstacles will need to be overcome before the successful implementation in the clinic of these novel attractive therapeutic strategies.


digestive diseases; immune tolerance; mesenchymal stromal cells; tissue regeneration


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