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Reprod Biomed Online. 2018 Apr;36(4):380-387. doi: 10.1016/j.rbmo.2018.01.001. Epub 2018 Feb 2.

Can time-lapse parameters predict embryo ploidy? A systematic review.

Author information

1
Service de Médecine et Biologie du Développement et de la Reproduction, CHU de Nantes, 38 boulevard Jean Monnet, Nantes, France; Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France; Faculté de Médecine, Université de Nantes, Nantes, France.
2
Service de Médecine et Biologie du Développement et de la Reproduction, CHU de Nantes, 38 boulevard Jean Monnet, Nantes, France; Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France.
3
Service de Médecine et Biologie du Développement et de la Reproduction, CHU de Nantes, 38 boulevard Jean Monnet, Nantes, France; Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France; Faculté de Médecine, Université de Nantes, Nantes, France. Electronic address: thomas.freour@chu-nantes.fr.

Abstract

Embryo morphology assessment performs relatively poorly in predicting implantation. Embryo aneuploidy screening (PGS) has recently improved, but its clinical value is still debated, and the development of a cheap non-invasive method for the assessment of embryo ploidy status is a highly desirable goal. The growing implementation of time-lapse devices led some teams to test the effectiveness of morphokinetic parameters as predictors of embryo ploidy, with conflicting results. The aim of this study was to conduct a comprehensive review of the literature on the predictive value of morphokinetic parameters for embryo ploidy status. A systematic search on PubMed was conducted using the following key words: time-lapse, morphokinetic, aneuploidy, IVF, preimplantation genetic screening, PGS, chromosomal status. A total of 13 studies were included in the analysis. They were heterogeneous in design, patients, day of embryo biopsy, statistical approach and outcome measures. No single or combined morphokinetic parameter was consistently identified as predictive of embryo ploidy status. In conclusion, the available studies are too heterogeneous for firm conclusions to be drawn on the predictive value of time-lapse analysis for embryo aneuploidy screening. Hence, morphokinetic parameters should not be used yet as a surrogate for PGS to determine embryo ploidy in vitro.

KEYWORDS:

Aneuploidy; Morphokinetic; Preimplantation genetic screening; Time-lapse

PMID:
29398421
DOI:
10.1016/j.rbmo.2018.01.001
[Indexed for MEDLINE]

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