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Neuron. 2018 Feb 21;97(4):885-897.e6. doi: 10.1016/j.neuron.2018.01.019. Epub 2018 Feb 1.

Small Networks Encode Decision-Making in Primary Auditory Cortex.

Author information

1
Department of Biology, University of Maryland, College Park, MD 20742, USA; Institute for Systems Research, University of Maryland, College Park, MD 20742, USA.
2
Department of Electrical and Computer Engineering, University of Maryland, College Park, MD 20742, USA.
3
Department of Biology, University of Maryland, College Park, MD 20742, USA.
4
Institute for Systems Research, University of Maryland, College Park, MD 20742, USA; Department of Electrical and Computer Engineering, University of Maryland, College Park, MD 20742, USA.
5
Department of Biology, University of Maryland, College Park, MD 20742, USA; Institute for Systems Research, University of Maryland, College Park, MD 20742, USA. Electronic address: pkanold@umd.edu.

Abstract

Sensory detection tasks enhance representations of behaviorally meaningful stimuli in primary auditory cortex (A1). However, it remains unclear how A1 encodes decision-making. Neurons in A1 layer 2/3 (L2/3) show heterogeneous stimulus selectivity and complex anatomical connectivity, and receive input from prefrontal cortex. Thus, task-related modulation of activity in A1 L2/3 might differ across subpopulations. To study the neural coding of decision-making, we used two-photon imaging in A1 L2/3 of mice performing a tone-detection task. Neural responses to targets showed attentional gain and encoded behavioral choice. To characterize network representation of behavioral choice, we analyzed functional connectivity using Granger causality, pairwise noise correlations, and neural decoding. During task performance, small groups of four to five neurons became sparsely linked, locally clustered, and rostro-caudally oriented, while noise correlations both increased and decreased. Our results suggest that sensory-based decision-making involves small neural networks driven by the sum of sensory input, attentional gain, and behavioral choice.

KEYWORDS:

2-photon; Granger; attention; auditory; behavior; cortex; decision-making; decoding; imaging; mouse

PMID:
29398362
PMCID:
PMC6289180
[Available on 2019-02-21]
DOI:
10.1016/j.neuron.2018.01.019

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