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Trials. 2018 Feb 5;19(1):48. doi: 10.1186/s13063-018-2440-y.

Global health trials methodological research agenda: results from a priority setting exercise.

Author information

1
Clinical Trials Research Centre, Biostatistics, University of Liverpool, Liverpool, UK. a.rosala-hallas@liverpool.ac.uk.
2
Academic Department of Surgery, Queen Elizabeth Hospital, Birmingham, UK.
3
Medical Research Council ConDuCT II Hub for Trials Methodology Research, School of Social and Community Medicine, University of Bristol, Bristol, UK.
4
Clinical Trial Service Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
5
Northern Ireland Network for Trials Methodology Research, Queen's University Belfast, Belfast, UK.
6
The Global Health Network, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
7
Peninsula Dental School, Plymouth University, Plymouth, UK.
8
South African Medical Research Council, Cape Town, South Africa.
9
Cochrane, London, UK.
10
Medical Research Council Clinical Trials Unit at University College London, London, UK.
11
Liverpool School of Tropical Medicine, Liverpool, UK.
12
Evidence Based Medicine Centre, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
13
North West Hub for Trials Methodology Research/Clinical Trials Research Centre, University of Liverpool, Liverpool, UK.

Abstract

BACKGROUND:

Methodological research into the design, conduct, analysis and reporting of trials is essential to optimise the process. UK specialists in the field have established a set of top priorities in aid of this research. These priorities, however, may not be reflected in the needs of similar research in low- to middle-income countries (LMICs) with different healthcare provision, resources and research infrastructure. The aim of the study was to identify the top priorities for methodological research in LMICs to inform further research and ultimately to improve clinical trials in these regions.

METHODS:

An online, two-round survey was conducted from December 2016 to April 2017 amongst researchers and methodologists working on trials in LMICs. The first round required participants to suggest between three and six topics which they felt were priorities for trial methodological research in LMICs. The second round invited participants to grade the importance of a compulsory list of topics suggested by four or more individuals, and an optional list of the remaining topics.

FINDINGS:

Rounds 1 and 2 were completed by 412 and 314 participants, respectively. A wide spread of years of experience, discipline, current country of residence, origin of trials training and area of involvement in trials was reported. The topics deemed most important for methodological research were: choosing appropriate outcomes to measure and training of research staff.

CONCLUSION:

By presenting these top priorities we have the foundations of a global health trials methodological research agenda which we hope will foster future research in specific areas in order to increase and improve trials in LMICs.

KEYWORDS:

Global health; Priority setting; Trials methodology

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