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Int J Colorectal Dis. 2018 Mar;33(3):349-352. doi: 10.1007/s00384-018-2965-2. Epub 2018 Feb 3.

Risk of colorectal cancer in patients with periodontal disease severity: a nationwide, population-based cohort study.

Author information

1
Division of Colorectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan.
2
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei City, Taiwan.
3
School of Medicine, National Defense Medical Center, Taipei City, Taiwan.
4
School of Public Health, National Defense Medical Center, Taipei City, Taiwan.
5
Department of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
6
Big Data Research Center, College of Medicine, Fu Jen Catholic University, No. 510, Zhongzheng Road, Xinzhuang District, New Taipei City, 24205, Taiwan, Republic of China.
7
Division of General Surgery, Department of Surgery, Chi-Mei Hospital, Tainan, Taiwan.
8
Division of Colorectal Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
9
Big Data Research Center, College of Medicine, Fu Jen Catholic University, No. 510, Zhongzheng Road, Xinzhuang District, New Taipei City, 24205, Taiwan, Republic of China. 040866@mail.fju.edu.tw.
10
Department of Public Health, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan. 040866@mail.fju.edu.tw.

Abstract

BACKGROUND:

Periodontal disease (PD) and colorectal cancer (CRC) were associated with chronic inflammation. This retrospective cohort study examined the association between PD severity and CRC in a large-scale, population-based Chinese cohort.

METHODS:

A total of approximately 106,487 individuals with newly diagnosed PD and 106,487 age-matched and sex-matched patients without PD from 2000 to 2002 were identified from Taiwan's National Health Insurance Research Database (NHIRD).

RESULTS:

The Kaplan-Meier analysis revealed that the cumulative incidence of CRC was significantly higher in patients with PD than in those without PD (log-rank test, P < 0.001). After adjustment for age, sex, and comorbidities, patients with PD were associated with a significantly higher risk of CRC compared with those without PD (adjusted HR = 1.64, 95% CI = 1.50-1.80). Further, the risk of CRC appeared to increase with increasing frequency of PD medical visits [adjusted HR (95% CI) was 1.78 (1.58-2.02) and 1.53 (1.35-1.74) for annual visits > 10 and < 4, respectively].

CONCLUSION:

Based on our study, PD severity was associated with an increase in the risk of CRC. Further mechanistic research is needed.

KEYWORDS:

Colorectal cancer (CRC); National Health Insurance Research Database (NHIRD); Periodontal disease (PD); Retrospective cohort study

PMID:
29397431
DOI:
10.1007/s00384-018-2965-2
[Indexed for MEDLINE]

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