Format

Send to

Choose Destination
Neuron. 2018 Feb 7;97(3):640-655.e4. doi: 10.1016/j.neuron.2017.12.034. Epub 2018 Jan 26.

Integration of Visual Information in Auditory Cortex Promotes Auditory Scene Analysis through Multisensory Binding.

Author information

1
The Ear Institute, University College London, London, UK.
2
Department of Biomedical Engineering and Department of Neuroscience, Del Monte Institute for Neuroscience, University of Rochester, Rochester, NY, USA; Institute for Learning and Brain Sciences and Department of Speech and Hearing Sciences, University of Washington, Seattle, WA, USA.
3
Institute for Learning and Brain Sciences and Department of Speech and Hearing Sciences, University of Washington, Seattle, WA, USA.
4
The Ear Institute, University College London, London, UK. Electronic address: j.bizley@ucl.ac.uk.

Abstract

How and where in the brain audio-visual signals are bound to create multimodal objects remains unknown. One hypothesis is that temporal coherence between dynamic multisensory signals provides a mechanism for binding stimulus features across sensory modalities. Here, we report that when the luminance of a visual stimulus is temporally coherent with the amplitude fluctuations of one sound in a mixture, the representation of that sound is enhanced in auditory cortex. Critically, this enhancement extends to include both binding and non-binding features of the sound. We demonstrate that visual information conveyed from visual cortex via the phase of the local field potential is combined with auditory information within auditory cortex. These data provide evidence that early cross-sensory binding provides a bottom-up mechanism for the formation of cross-sensory objects and that one role for multisensory binding in auditory cortex is to support auditory scene analysis.

KEYWORDS:

attention; auditory cortex; auditory-visual; binding; cross-modal; ferret; multisensory; sensory cortex; visual cortex

PMID:
29395914
PMCID:
PMC5814679
DOI:
10.1016/j.neuron.2017.12.034
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center